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Department of Chemistry and Biochemistry receives a NSF Major Research Instrumentation Award

Bruker AVANCE III HD Ascend 400 MHz NMR with Multinuclear Broad Band Smart Probe.

A team of faculty members in the Department of Chemistry and Biochemistry was awarded $333,504 from the National Science Foundation for the acquisition of a 400 MHz nuclear magnetic resonance (NMR) spectrometer with an autosampler and auto-tune multi-nuclei SmartProb.

NMR spectroscopy is a routine analytical method central to the practice of chemistry and biochemistry for the characterization of substances and study of molecular behavior. The instrument will provide faculty and students with the fundamental and necessary analytical technology to support the increasingly complex and diverse research programs in human health, bio-organic synthesis, and environmental science.

The new instrument will be used for a variety of different research projects including the:

  • Structural characterization of chiral tricyclic lactams by 2D NMR;
  • Characterization of inorganic non-heme iron nitrosyl complexes of biological importance to the understanding of NO generation;
  • Development of triserine lactone receptors for the binding of anions;
  • Characterization of poly functional gold nanoparticle-cored dendrimers towards the treatment and imaging of cancer;
  • Development of novel organophosphorus butyrylcholinesterase inhibitors as Alzheimer's disease therapeutics; and the
  • Study of selective small molecule membrane binding and transport using synthetic receptors.

PI: Michael P. Schramm, CoPIs: Paul Buonora, Lijuan Li, Eric Marinez, Stephen Mezyk, Ken Nakayama, Jason Schwans and Young Shon.